Ikizamini gishya cya Hangzhou cyatangije ibihe-byo gutungwa no gusuzuma amatungo mashya - Canine na Feline Renal Imikorere 3-muri-1 combo Ikizamini
Hangzhou New-Test Biotechnology Co., Ltd yatangaje ku mugaragaro ko hashyizweho ku mugaragaro ibicuruzwa bibiri bishya byo gusuzuma amatungo ku isoko mpuzamahanga ry’imiti isuzuma indwara: Canine / Feline imikorere yimpyiko ya Triple Test Kit (Creatinine / SDMA / CysC Triple Test) (Igishushanyo 1 na Ishusho 2), bizana igisubizo gishya kandi gisobanutse kubisuzuma byubuzima bwamatungo no kuvura.
Igishushanyo 1 Canine impyiko imikorere yikizamini cya gatatu Igice cya 2 Igikoresho cyimpyiko yimikorere itatu
Mu Kwakira 2022, New-Test Biotechnology Co., Ltd. niyo yabaye iya mbere mu gushyira ahagaragara isesengura rya mbere ry’imiyoboro myinshi ya Multlex fluorescence immunoassay isesengura, NTIMM4 (igisekuru cya gatatu, reba Ishusho ya 3), naho mu 2024, umuyoboro mushya wa Multlex immunofluorescence isesengura, NTIMM2 (igisekuru cya kane, reba Ishusho ya 4). Imikorere iheruka ya canine / feline yimpyiko 3-muri-1 combo yipimisha ibikoresho birahuza na moderi zombi.
Igishushanyo 3 NTIMM4 Igishusho 4 NTIMM2
Inzobere muri molekile ntoya isuzuma ubushakashatsi niterambere mumyaka itandatu, ibicuruzwa bishya biratangizwa.
Ukuri kwa molekile ntoya kwamye kwabaye ingorabahizi kunesha mubijyanye no gupima POCT, kandi nicyerekezo cyubushakashatsi niterambere Nest-Test Bio yitangiye kuva yashingwa hashize imyaka irenga 6. Kuzimya umubiri no kubora biranga ibikoresho gakondo bya fluorescent bigira ingaruka kuburyo butaziguye kubisubizo bya molekile nto. Ikoreshwa rya tekinoroji ya nanocrystal idasanzwe, igisekuru cya kane cya fluorescent nanomaterial yakozwe na New-Test, izwi nka nanomateriali ya fluorescent ihamye ku isoko, ifite inyungu zo gutsinda ibiranga umubiri biranga kuzimya urumuri. Hamwe nimyaka myinshi yo gukomeza kunoza imikorere, yarangije gukemura ikibazo cyisi yose yo kutamenya neza mugupima molekile nto ya POCT. Gusunika kwambere nigikorwa cyimpyiko inshuro eshatu zipimisha. Iremeza neza kandi ihamye ya molekile ebyiri nto (creatinine & SDMA) igaragara mugihe cyimyaka 2 yemewe.
“Ikizamini kimwe nacyo kirahari, none kuki utezimbere imikorere yimpyiko”—— Umwanya witerambere ryimikorere yimpyiko triad
Kugeza ubu, ibipimo rusange byerekana imikorere yimpyiko idasanzwe mu mbwa ninjangwe harimo creinine (CREA) na azote ya urea muri biochemie; C. Iyo igipimo cyo kuyungurura isi kigabanutse kubera gukomeretsa kw'impyiko, ibi bipimo bizegeranya mu maraso kandi byiyongere mu kwibanda, bityo bikagaragaza urugero rw'impyiko - imikorere mibi. Sosiyete mpuzamahanga ishinzwe ubushakashatsi mu ndwara zifata impyiko (IRIS) ishyira mu byiciro ubumuga bw’impyiko mu njangwe mu byiciro bine bishingiye ku gaciro ka creinine (Icyiciro cya mbere, gisanzwe cyangwa cyoroheje: <1,6 mg / dL; Icyiciro cya II, giciriritse: 1,6-2.8 mg / dL Icyiciro cya III, gikomeye: 2.8-5.0 mg / dL;
Ubumuga bw'impyiko mu mbwa bushyirwa mu byiciro bine (Icyiciro cya mbere, gisanzwe cyangwa cyoroheje: <1.4 mg / dL: Icyiciro cya II, giciriritse: 1.4-2.0 mg / dL: Icyiciro cya III, gikomeye: 2.0-4.0 mg / dL: Icyiciro cya IV, n'icyiciro cya nyuma:> 4.0 mg / dL). Icyakora, kubera ubukangurambaga buke bwa creinine mu ndwara zidakira zidakira (CKD), hakoreshejwe ikindi kimenyetso mbere cyerekana imikorere ya nephron, “simmetric dimethylarginine (SDMA)”. Dukurikije imibare, SDMA irashobora kwerekana ibintu bidasanzwe kuri 25-40% yubumuga bwimpyiko, mugihe creinine isanzwe ifatwa nkibidasanzwe kuri 75% yubumuga.
CysC (cystatin C) ni inhibitor ya sisitemu ya protease, uburemere buke bwa molekile (13.3 kD), proteine yibanze ya glycosilated. Nibimwe mubimenyetso bikoreshwa cyane mumikorere yimpyiko hakiri kare mubuvuzi bwabantu. Kimwe na creinine na SDMA, irayungururwa binyuze muri glomerulus, ariko itandukanye na creinine na SDMA kubera ko metabolisme yayo itanyuze mu nzira yinkari, ariko hafi ya yose ihinduranya na reabsorption ikoresheje tubules yimpyiko.Ni iri tandukaniro rito ariko ryingenzi rifite ntibyigeze bigaragara mbere, biganisha ku bahanga benshi, abahanga n’ubuvanganzo ku myanzuro ibiri itandukanye yerekeye gukomeretsa impyiko zidakira mu njangwe: bamwe bemeza ko CysC ari ikimenyetso cyambere cyo gukomeretsa impyiko zidakira zishobora gukoreshwa muri yombi imbwa ninjangwe, mugihe abandi bemeza ko CysC ifitanye isano iri hagati ya cine CKD, ariko mubi injangwe.
Ni ukubera iki hariho imyanzuro ibiri itandukanye uhereye kuri "glomerular filtration function index"?
Impamvu ni Anuria, ikaba ari indwara yiganje mu njangwe kuruta mu yandi moko, cyane cyane mu njangwe z'abagabo. Amakuru amwe yerekana ko indwara ya Anuria mu njangwe z’abagabo igera kuri 68,6%, kandi Anuria izavamo mu buryo butaziguye kubuza gusohoka kwa creinine, azote ya azure na SDMA. Ibinyabuzima bihora bisimburana kandi bikabyara creinine nshya, azure ya azure ya azure na SDMA, mugihe hagaragaye ibimenyetso byose uko ari bitatu mumaraso muriki gihe, hazabaho kwiyongera gukabije cyangwa no guturika kwerekanwa nubwo glomerulus yangiritse koko.
CysC ifite agaciro kayo muri iki gihe, nubwo iki kimenyetso ari filteri yisi yose, ntabwo ihindurwa ninkari, inyura muri tubular kugirango reabsorption. Iyo Anuria ibaye ariko imikorere yimpyiko nibisanzwe, indangagaciro ya CysC irashobora gukomeza kubungabungwa kurwego rusanzwe. Gusa iyo glomerulus cyangwa ibyangiritse byangiritse mubyukuri, indangagaciro ya CysC izamurwa muburyo budasanzwe. Kubwibyo, gutahura ibipimo bitatu byose birashobora kwisuzumisha neza kandi bigatanga ubuvuzi bukwiye vuba kandi neza.
Imikorere mishya yimikorere yimpyiko 3-muri-1 ibikoresho byipimisha bitanga ibisobanuro bishya byubuvuzi mugutahura ibikomere byimpyiko nimbwa ninjangwe!
Gusobanura amahame no guhuza n'ibiranga ibipimo, ibimenyetso bishya byerekana imikorere yimpyiko 3-muri-1 byavutse bifite akamaro gakomeye mubuvuzi bwimbwa ninjangwe (cyane cyane injangwe) na Anuria:
Ikizamini gishya cyibikorwa byimpyiko 3-muri-1 yipimisha ikoreshwa mugutandukanya niba hari imvune yimpyiko nyayo mumiterere ya Anuria cyangwa bikaviramo kuzamuka kwizamuka ryibipimo kubera Anuria. Imvune yimikorere yimpyiko isaba gusa catheterisiyasi yinkari hamwe nubuvuzi bujyanye nayo, kandi prognoz ni nziza muri rusange. Kuzamuka kw'ibipimo ntibisaba gusa catheterisiyasi yinkari no kuvura anti-inflammatory, ahubwo bisaba no kuvura bifitanye isano n'indwara zimpyiko, kandi guhanura biragoye, kandi birashoboka cyane ko byahinduka indwara zimpyiko zidakira.
Hano hepfo haribimenyetso bishya byerekana imikorere yimpyiko 3-muri-1 yipimisha ibikoresho bya Anuria isanzwe (Imvune zidahwitse zimpyiko) na Anuria + ibikomere byimpyiko mubibazo byubushakashatsi bwubuvuzi bushya:
| Anuria Ikizamini-gishya cyimikorere yimpyiko 3-muri-1 ibikoresho byo kwipimisha | Umushinga | Igisubizo | Igisubizo |
| Kurema | + | + | |
| SDMA | + | + | |
| CysC | + | - | |
| Umwanzuro | Anuria byaviriyemo gukomeretsa impyiko | Icyiciro cya mbere cya Anuria no gukomeretsa kw'impyiko cyangwa Anuria itaragera ku gikomere cy'impyiko |
Hasi ni igice cyibintu bisanzwe byubuvuzi hamwe nibisobanuro byerekana imikorere mishya yimpyiko 3-muri-1 y'ibizamini:
| Injangwe | Amateka y'Ubuvuzi | Ikimenyetso cya Clinical | CysC (mg / L) | SDHA (ug / dL) | CR (mg / dL) | Umwanzuro |
| 2024090902 | Cystitis / Gukomeretsa bikabije | Imitekerereze mibi, Gutakaza ubushake, Indwara idasanzwe yimpyiko, Anuria (Kunanirwa kwimpyiko zidakira, anuria) | 1.09 | 86.47 | 8.18 | Gukomeretsa impyiko hamwe na Anuria |
| 2024091201 | / | Imitekerereze mibi, Anuria, Imikorere idasanzwe yimpyiko | 0.51 | 27.44 | 8.21 | Nta gukomeretsa kw'impyiko hamwe na Anuria / Icyiciro cya mbere |
| 2024092702 | / | Anuria | 0.31 | > 100.00 | 9.04 | Nta gukomeretsa kw'impyiko hamwe na Anuria / Icyiciro cya mbere |
| 2024103101 | / | Anuria | 0.3 | 14.11 | 6.52 | Nta gukomeretsa kw'impyiko hamwe na Anuria / Icyiciro cya mbere |
| 2024112712 | Anuria | 0.5 | > 100.00 | 8.85 | Nta gukomeretsa kw'impyiko hamwe na Anuria / Icyiciro cya mbere | |
| 2024112601 | Dysuria / Anuria | 0.43 | > 100.00 | 9.06 | Nta gukomeretsa kw'impyiko hamwe na Anuria / Icyiciro cya mbere | |
| 0.47 | > 100.00 | 878 | Nta gukomeretsa kw'impyiko hamwe na Anuria / Icyiciro cya mbere | |||
| 2024112712 | / | Anuria | 0.54 | 94.03 | 8.64 | Nta gukomeretsa kw'impyiko hamwe na Anuria / Icyiciro cya mbere |
Muburyo bwa Anuria, kubera itandukaniro muburyo bwimikorere ya metabolike yimbere ya buri cyegeranyo, hazavamo itandukaniro rinini kumikorere yimpyiko imwe. Kubwibyo, gushyira muburyo busanzwe bwo gukomeretsa kwimpyiko za creinine cyangwa SDMA ntibikigikoreshwa, kandi umwanzuro wamavuriro wa hafi ushobora kuboneka gusa muguhuza isesengura nibindi bimenyetso "CysC". Birasabwa ko laboratoire (ibitaro) zishyiraho ibipimo byimbere bishingiye kuburambe bwubuvuzi, kugirango tumenye akamaro k’amavuriro.
Hanyuma, New-Test Biotech yizera ko iyi ngingo izajugunya amatafari kugirango ikurure jade, kandi yizera ko imiti myinshi y’amatungo y’abashinwa n’abakora imiti igabanya ubukana izateza imbere ibicuruzwa bifite akamaro kanini kandi bigafasha abaveterineri b’amavuriro bo mu rugo kugera ku rwego rwo hejuru muri isi!
Umugereka: Kwemera Porogaramu isaba Kurinda Umutungo Wubwenge
Igihe cyo kohereza: Mutarama-22-2025
